Progesterone Shots: Preventing Premature Birth

My son was born premature at 32 weeks, so my current pregnancy was considered high risk from the start, based on my history. Six months ago, my ob recommended weekly shots of 17p alpha-hydroxyprogesterone between weeks 20 – 36 of my pregnancy.

When we began discussing my options, a weekly appointment just to get my shot did not seem feasible: driving an hour or more each week, waiting, getting the shot, finding babysitting every week (and it had to be the same day each week). Of course, I wanted the shots, for the sake of our child. I was willing to do almost anything to avoid having another NICU baby, another baby coming home on the apnea/brady monitor, the endless possibilities of health problems for a premature child.

So we explored alternatives: the most viable one seemed to be the “do-it-yourself” way–ordering the shots from an online pharmacy with my husband administering them at home.

At the time, just the thought of my husband administering these shots gave me chills.

When we got married, our vows included the “in sickness and in health” line. But while you’re standing at the altar, that line seems so understood–even innocuous. (I mean, we all get colds, right? and let me tell you, I’ll be there for you.) You’re not reading between the lines, thinking, ‘in giving [or receiving] weekly shots for several months of pregnancy and bedrest.’

My husband loves me. And I knew he would do the very best he could while giving me my shots. But he’s not at all the medical type. He was repulsed by the doctor’s suggestion that he cut the umbilical cord (‘That’s why we pay you the big bucks!’ my husband replied) and he had no interest in “observing” the baby’s birth in any way whatsoever, except to hold the child–after a thorough bath.

Having experienced various pain levels while receiving shots, I assumed that smoothly administering shots–especially shots that were “thick” enough they have to be administered in your rear end–required years of medical training and experience.

So it was with a bit of trepidation that we had a home health care nurse come out to show him how it was done for the first two weeks. After that, he’s been on his own.

To my great surprise (and even delight!), my husband does a better job administering the shots than the home health care nurse! It’s been less painful–and not even as messy.

During four months of shots, I have. . .

  • Had about three months of contractions (frequently 3-5 minutes apart especially during the night).
  • Significantly reduced my activity (grocery shopping, carrying laundry, lifting the kids, “outings”) in order to avoid bedrest.
  • Spent four days in the hospital during week 29, attempting to bring my contractions down to a reasonable level.
  • Made several trips to Labor and Delivery Triage with contractions 5 minutes apart (or less).
  • Been taking procardia (nifedipine) for about a month and a half.
  • Had a shot of terbutaline, which was a huge success in reducing contractions that were 2-3 minutes apart down to only a handful per hour.
  • Spent about a month and a half on bedrest.

With all of this contraction “activity,” I never imagined that I would still be pregnant at week 36. I never would have believed that my husband would have the chance to give me all 17 shots.

But here we are–17 shots later.

My last shot was earlier this week. We don’t need this stuff any more! As my 3-year-old daughter told someone today, “Mommy’s p’gesterone shots are all gone now!”

And next week, I will be 37 weeks–full-term!

It worked! It wasn’t easy, and it may have been the combination of progesterone, procardia, bedrest, terbutaline. . . but we don’t have a preemie this time around!

So my little girl will be one more success story, speaking to the effectiveness of progesterone shots in reducing premature births!

This Works for Me!

“I Mean, It’s not Crack . .”

That was the nurse practitioner describing the tocolytic I was about to receive.

So, yes, I ended up back in L&D triage this afternoon. After strong contractions four minutes apart through the early (sleepless) morning hours, and then waking up with contractions (not as strong but still four minutes apart), I spent most of my day “contracting.”

Daniel was working from home today, and he decided I really should call the doctor (and we knew the doctor would say to go to triage). So there we were. Again.

We asked our friend Bill, who is working on his dissertation, to come over and sit in the living room during the kids’ naps, which he most graciously did. . .

I know I’m emotional with pregnancy and all, but I really had a hard time putting the kids down for their naps and saying good-by. I was afraid they were going to increase my procardia (like they did with Micah), and it would do nothing for my contractions, but I would have blood pressure issues, and they would have to keep me on the Mom Unit (like they did with Micah).

Once my now-19-month-old Micah was in bed, I sang to him “Great is Thy Faithfulness” (more for me than for him) and then he held up one finger like he does everytime I put him to bed these days, and said, “Muh mo’.” [one more] So I sang one more. He did it again, and I had to say ‘That’s all, buddy. I know you’d have me sing all day long if you could.’

When we got to the hospital, Daniel insisted on pushing me up to Labor and Delivery in a wheelchair, despite the fact that I felt like a total wimp. I said I was pretty sure I could walk, and if I walked, the nurses would have adequate proof that I really was having a lot of contractions. He said we weren’t trying to impress the nurses with how many contractions I was having. I knew he was right–if I had walked, I’m sure my contractions would have just multiplied. He’s a good husband–he’s just what I need.

There were no beds available in triage when I arrived, so we were sent to the waiting room with a huge crowd of people awaiting news on a set of triplets that was to be born that day. Apparently the mom had chosen not to find out whether the babies were boys or girls! (Can you imagine? They had picked out three boys’ names and three girls’ names and were waiting to see what she delivered! Daniel said to me, “With all the logistical challenges in having triplets, why would you add one more by not finding out what they were?” So if we ever have triplets, you know we’ll be finding out whether they are boys or girls or a combination.)

When I did get a bed in “LD,” it was the same old routine: urine sample, hospital gown, cervical exam, various swabs/samples, blood drawn, IV fluids, monitoring the baby’s heart rate, my heart rate, and my contractions. My contractions were steady, 2-3 minutes apart, but varied in intensity. I think they felt worse because I hadn’t slept much last night–I felt nauseous and yucky–and I didn’t know if that was just fatigue or the ever-illusive “something different.”

The nurse practitioner checked my cervix and said, “It’s a loose one.” But it’s still a one, which means after all these contractions, I’ve had basically no cervical change! That was just not the case with Micah. But with Micah they had also waited to put me on any tocolytics until I was already 3 cm and 70% effaced. I’m sure it helps that I’ve been on progesterone for 12 weeks now and procardia for about 2-1/2 weeks.

While they monitored me and waited for results of the fetal fibronectin test, Daniel and I discussed baby names. Unfortunately, I can’t discuss what we discussed, but it was really one of the first opportunities we’ve had to sit and go through names together. I was glad I had made a list, glad Daniel brought his laptop (with my list on it). And surprised by the names he liked and didn’t like. There was one name–a beautiful name–from my list that Daniel contemplated for about half an hour. I was beginning to think it would be Little Boo’s name! While Googling the names’ meaning/ trendiness/ etc, Daniel learned something that completely ruled the name out for him. For one reason or another, every name was scratched off my list. And when Daniel began suggesting new names, there were none that really “grabbed” both of us.

In the end, we arrived back at the name we’ve been contemplating–but got hung up on the spelling. (And no, it doesn’t begin with an ‘M.’ But that’s the only hint I’m giving!) It is still not set in stone, because both of us have a pretty strong opinion on how we’ve “always envisioned” spelling it. We may have to scrap the name altogether and start over. 😉

But I was encouraged that we had the chance to discuss names. Probably we will settle on something soon, and she won’t spend her first three days nameless as Micah did!

My favorite news of the day was that the fetal fibronectin test came back negative again. That means there’s a 99% chance I will not deliver before two weeks from today (almost 35 weeks!). I was so excited that I told Daniel I was going to take myself off bedrest to celebrate! A 35-weeker sounds great to me! At that point, most of the lung development issues are resolved, and many babies can suck well enough at that point that they wouldn’t need tube feeds.

Of course, I was kidding about taking myself off bedrest. But comments like that always scare Daniel. (Sorry dear! Didn’t mean to–I’m just excited!) He started asking me questions like ‘What are the characteristics of the 1% that does deliver within two weeks? Do they have all your symptoms? It seems like you’re in the 1% on everything else–why should this be different?’

The question remained: What to do with all these contractions? Supposedly I’m on–not one, but two–drugs that should be keeping me from contracting.

Marianne, the nurse practitioner, asked about my progesterone and procardia dosage, then went to consult with Dr. C. We overheard the entire conversation.

“She’s contracting like crazy,” we heard her say. “But she’s still only a one.” Marianne recommended terbutaline, which I had read is the tocolytic most commonly given to stop preterm labor. I remembered one of my favorite preemie-mom-bloggers, Heather Spohr from The Spohrs Are Multiplying, being given terbutaline for preterm contractions.

I always wondered why I was given the procardia (nifedipine) instead during both pregnancies. Dr. C approved the terbutaline, so Marianne came to tell me more. It’s a drug that is commonly given orally to treat asthma, by dilating air passages in the lungs. In pregnant patients, terbutaline is injected into the arm and apparently reduces contractions by relaxing the muscles in the uterus. She told us side effects include: tremors, nausea, nervousness, dizziness, headache, drowsiness, heartburn, heart palpitations, fast heart rate, and elevated blood pressure. [Oooo, elevated blood pressure! So between procardia lowering my blood pressure and terbutaline elevating it, my blood pressure should be completely normal, right?] She said the primary feelings patients describe are heart palpitations, shakiness/the “jitters,” and headaches.

Honestly, as she described it to me, I was skeptical. I’m on bedrest. Progesterone. And procardia. They’re not working. Sure, add some terbutaline. It can’t hurt, right?

I think she could read me.

She insisted that it works really fast–within 20 minutes–and added, “It’s really good stuff! . . . I mean, it’s not crack. . .”

Oh, good.

I wish I had taken a picture of the contraction monitor! The graph displayed a constant stream of “hills” and “valleys” with each contraction 2-3 minutes apart. Then suddenly I was given my shot of terbutaline, and the graph literally flat-lined.

I was in awe. I did not know that a drug like this existed! (Although I have to say, my heart racing and jitters felt a lot like the side effects of an epi pen administration. And I came home with a headache–but very few contractions.)

Marianne told us it isn’t a “permanent” fix, but at least, we were able to stop my contractions one more time and buy our Little Boo a few more days, or maybe even weeks. She said we did the right thing coming in and she promised Dr. C that I was “very reliable, and she was sure I would come right back if there was anything unusual.”

I nodded heartily in agreement, while Daniel made some comment about having to twist my arm to get me up here. (Shhh! I want to go home tonight and see our kids!!)

So the combination of the negative result on my fetal fibronectin test and my very positive response to the terbutaline, was enough for Dr. C, who said I could go home.

Personally I think they needed my bed there in triage. There were more pregnant women in the waiting room.

And I was most willing to give it up!

When we got home, Mara greeted me with the most enthusiastic tears of joy imaginable from a three-year-old. Daniel’s mom said she had a hard time when she woke up, dealing with the fact that I was in the hospital again. I guess Micah handled it much better. While Mara hugged me (and wouldn’t let go), Micah hugged Daddy’s legs saying “Dadda!” I guess he knew he should be hugging somebody at that moment.

I’m still pinching myself. I really expected them to try increasing my procardia, and then (when that didn’t work) to keep me, at least overnight. I really didn’t expect a single shot to knock out my contractions. And I really expected to go to bed without my dear family tonight.

“It’s not crack,” but it’s pretty amazing, that terbutaline!

Today is THE DAY

No, dear, if you’re reading this, I’m not in labor. . . Just reminiscing up here in my bed!

Today is the day gestationally (in my last pregnancy) that Micah was born.

I told Daniel this last night, and he found it disturbing: “Really?! YIKES!”

I thought it was encouraging–a positive thing! I mean, I’m hardly even dilated this time (every woman who has had  a baby before is currently 1 cm, right?). And while I am contracting, on progesterone, procardia and bedrest, at least I’m not in the hospital like I was before Micah was born.

I’m not thinking our little girl will make it to her due date (March 6th), but every day from this point on is an “extra” day that she’s growing and developing in the womb, where she belongs right now, instead of in the NICU.

So I have to say, today was a big milestone for Little Boo and me!

Is The Tide Turning?

I have just a few minutes for a quick post tonight after quite the busy day. (And if you’re wondering ‘how can a day be “busy” on bedrest?’ well, that’s a post for another time! Sometimes I think it is three times as busy on bedrest as it is not on bedrest. It’s just a very different kind of busy. And it’s definitely three times more complicated!)

Anyway. . . my 32-week appointment!

Amazingly, I am still 1 cm!  I really couldn’t believe it.

Over the past few weeks, the idea at every appointment (or triage visit or hospital stay) has been ‘let’s see how we can manage these contractions and try to keep the baby inside as many more days as we can.’  Today the tone of my appointment was completely different. We’re not talking days now, we’re talking weeks. In fact, Dr. Z told me she was optimistic that if my “cervix continues to behave, maybe we can make it to week 37!”

This is the first talk of “week 37.” This is the first time the obs have discussed coming off bedrest, progesterone or procardia.

This is a stage I never experienced with Micah. With Micah’s pregnancy, we knew he would be premature, it was just a matter of how premature. I never asked about coming off bedrest or procardia–I clung to them as the only hope for keeping my child inside–growing stronger and staying healthy.

So mentally, this is a shift for me.

Someone from church wrote to ask what help we could use with meals and childcare, so Daniel asked me to write up a schedule for the next four weeks (Four weeks!) of who is helping which days and determine when we have gaps.

Today we found out that Daniel’s boss granted permission to work from home two days/week, which will be a huge blessing. But obviously he will technically still be working, right? so it would still be best for me to have some help for a couple of hours on those days.

We’re working the schedule out.

I told my Due Date Buddy Donna that we should team up and write a book: On Surviving Bedrest. 🙂 Maybe in four weeks I’ll have this thing figured out. Ha!

That said, I have to be careful. I’m feeling so encouraged, but I need to remember how much worse my contractions were before bedrest and procardia. There are no guarantees.

But I am starting to imagine what it’s like to room with your baby after she’s born, to nurse her right away, to bring her home when you leave the hospital. . . it all seems a bit too good to be true! I think I may need to pack a diaper bag and have the carseat ready!

For now, I’m just taking one day at a time. On bedrest. For the Little Boo.

But I’m asking myself, is the tide turning? Is this the week where we begin to see a marked difference between my pregnancy with Little Q (Micah) and my pregnancy with Little Boo? . . . only time will tell.

Little Boo Has Made It to 32 Weeks

I’m so excited that we’ve made it to 32 weeks!

There are times when bedrest is very difficult, but having a child in the NICU (especially with other toddlers at home) is far beyond the “difficulty” that is bedrest. So I am trying to be thankful for bedrest.

From now through January 22, I’m “holding my breath” because Dr. Smith, our perinatologist, told us that most “repeat” preemie births occur within one week on either side of the first preemie birth. So the chances are, if I were to deliver Little Boo prematurely, she would come between now and January 22.

January 15th will be an exciting milestone: the “WooHOO!-She-Made-It-Further-Than-Micah” Day. So in some ways, this is a big week for us.

My next appointment is Monday. By that time (in Micah’s pregnancy), I was 70% effaced, and 3 cm dilated. So I’m very very curious whether Dr. Z will notice any cervical changes tomorrow.

I have to admit a bit of nervousness, though, because I was hospitalized during that week of Micah’s pregnancy. And while I will take my overnight bag, just in case, I really really really hope I will just be coming back home again–on bedrest.

Isn’t it weird how your perspective can change with the circumstances? A month ago, I was dreading bedrest. Now I’m praying that’s all it will be!